Integration of miRNA-lncRNA-mRNA profiles in liver tissue from EpCAM knockout mice
نویسندگان
چکیده
The epithelial cell adhesion molecule (EpCAM) is highly expressed in the liver during development and diseases. However, its role pathology of remains to be explored. tissues EpCAM-/- wildtype (WT) mice at P0 stage were used for RNA sequencing. differently miRNAs, lncRNAs mRNAs selected confirmed by qPCR. expression metabolism-related gene SET domain bifurcated 2 (Setdb2) was significantly increased mice; triglyceride (TG) total cholesterol (TC) levels also markedly decreased mice. microRNA (miRNA)-long noncoding (lncRNA)-mRNA regulatory networks indicated that EpCAM may play important roles glucose lipid metabolism disease. comprehensive miRNA, lncRNA mRNA profiles developing established here might help elucidate functions mechanisms diseases liver.
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ژورنال
عنوان ژورنال: Archives of Biological Sciences
سال: 2022
ISSN: ['1821-4339', '0354-4664']
DOI: https://doi.org/10.2298/abs211207001l